Theoretical and experimental evaluation of continuous arterial spin labeling techniques

Continuous arterial spin labeling is known to be the most sensitive arterial spin labeling technique. To avoid magnetization transfer effects and to overcome hardware limitations, several sequences have been proposed that adiabatically label the inflowing blood. Four of these methods are examined with respect to their sensitivity both theoretically by Bloch equation simulations and experimentally. All sequences were optimized carefully by adjusting their measurement parameters based exclusively on the results of simulations. Perfusion measurements on the human brain obtained at 3 T result in excellent images from all techniques, while differences in sensitivity are similar to those expected from the simulations.