TY - JOUR
T1 - Thiolsulfonate functionalized polystyrene resin
T2 - Preparation and application in the isolation and identification of electrophilic mutagens
AU - E, Wu
AU - Carlson, Robert M.
PY - 2007
Y1 - 2007
N2 - A new approach for isolation and identification of elecrtophilic mutagens from complex matrix was developed. Thiosulfonic anion was immobilized onto polystyrene beads and used as separation media. Potassium polystyryl-thiosulfonate, prepared from polystyrylsulfonyl chloride and KHS, was observed to selectively react with model electrophilic mutagens such as alkyl halides, α-chloroketones and α-chloroesters to produce polystyryl-thiosulfonic esters. After separation from other nonreactive organic compounds, the beads then reacted with ethanethiol to produce unsymmetrical ethyl disulfides which are easily detected by GC/MS. For one mutagenic compound, only one unsymmetrical disulfide was found to contain its structure part. Thus, the structure of the parent mutagens could be deduced from that of the unsymmetrical disulfides. The degree of functionalization of the potassium polystyryl-thiosulfonate resin was 1.11 mmol/g. Its reactivity was discussed and its recycling method was reported here.
AB - A new approach for isolation and identification of elecrtophilic mutagens from complex matrix was developed. Thiosulfonic anion was immobilized onto polystyrene beads and used as separation media. Potassium polystyryl-thiosulfonate, prepared from polystyrylsulfonyl chloride and KHS, was observed to selectively react with model electrophilic mutagens such as alkyl halides, α-chloroketones and α-chloroesters to produce polystyryl-thiosulfonic esters. After separation from other nonreactive organic compounds, the beads then reacted with ethanethiol to produce unsymmetrical ethyl disulfides which are easily detected by GC/MS. For one mutagenic compound, only one unsymmetrical disulfide was found to contain its structure part. Thus, the structure of the parent mutagens could be deduced from that of the unsymmetrical disulfides. The degree of functionalization of the potassium polystyryl-thiosulfonate resin was 1.11 mmol/g. Its reactivity was discussed and its recycling method was reported here.
KW - electrophilic mutagens
KW - functionalized polystyrene
KW - potassium polystyryl-thiosulfonate
KW - unsymmetrical ethyl disulfides
UR - http://www.scopus.com/inward/record.url?scp=36949038757&partnerID=8YFLogxK
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U2 - 10.1016/S1001-0742(07)60248-4
DO - 10.1016/S1001-0742(07)60248-4
M3 - Article
C2 - 18277660
AN - SCOPUS:36949038757
SN - 1001-0742
VL - 19
SP - 1520
EP - 1527
JO - Journal of Environmental Sciences
JF - Journal of Environmental Sciences
IS - 12
ER -