Tissue-Resident T Cells and Other Resident Leukocytes

David Masopust, Andrew G. Soerens

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


Resident memory T (Trm) cells stably occupy tissues and cannot be sampled in superficial venous blood. Trm cells are heterogeneous but collectively constitute the most abundant memory T cell subset. Trm cells form an integral part of the immune sensing network, monitor for local perturbations in homeostasis throughout the body, participate in protection from infection and cancer, and likely promote autoimmunity, allergy, and inflammatory diseases and impede successful transplantation. Thus Trm cells are major candidates for therapeutic manipulation. Here we review CD8+ and CD4+ Trm ontogeny, maintenance, function, and distribution within lymphoid and nonlymphoid tissues and strategies for their study. We briefly discuss other resident leukocyte populations, including innate lymphoid cells, macrophages, natural killer and natural killer T cells, nonclassical T cells, and memory B cells. Lastly, we highlight major gaps in knowledge and propose ways in which a deeper understanding could result in new methods to prevent or treat diverse human diseases.

Original languageEnglish (US)
Pages (from-to)521-546
Number of pages26
JournalAnnual Review of Immunology
StatePublished - Apr 26 2019

Bibliographical note

Funding Information:
This work was supported by R01 AI111671 and R01 AI084913 (D.M.) and T32HL007741 (A.G.S.)

Publisher Copyright:
© Copyright 2019 by Annual Reviews. All rights reserved.


  • T lymphocytes
  • immunity
  • lymphoid cells
  • memory
  • residence


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