Toward an understanding of liposome structure through the use of computer graphic image correlation

Joseph A N Zasadzinski, John Kerins, H. T. Davis, L. E. Scriven

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A computer‐aided graphics approach to correlating transmission electron microscope images of freeze‐fractured and thin‐sectioned samples is outlined. Any three‐dimensional model of the imaged structure can be mathematically sectioned to provide a two‐dimensional representation of the model in the “fracture” plane. The method is used to demonstrate that the structure of lamellar liquid crystalline liposomes is based on a family of Dupin cyclides; closed, parallel surfaces with a conjugate ellipse and hyperbola as curvature defects.

Original languageEnglish (US)
Pages (from-to)385-400
Number of pages16
JournalJournal of Electron Microscopy Technique
Volume3
Issue number4
DOIs
StatePublished - 1986

Keywords

  • Freeze fractures
  • Liquid crystal
  • Vesicles

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