TY - JOUR
T1 - Transgenic Alzheimer mice have a larger minimum alveolar anesthetic concentration of isoflurane than their nontransgenic littermates
AU - Eckel, Barbara
AU - Richtsfeld, Martina
AU - Starker, Laura
AU - Blobner, Manfred
N1 - Funding Information:
Supported by Kommission für klinische Forschung (KKF No. 87681174-Blo/Rie/Eck/Ohl ) and Novartis, Basel, Switzerland (animals).
PY - 2010/2
Y1 - 2010/2
N2 - Background: More than 12% of all people older than 65 yr have Alzheimer's disease. Because nothing is known about changes in demand of volatile anesthetics in this disease, we determined minimum alveolar anesthetic concentration (MAC) values of isoflurane in young and aged transgenic mice at risk of developing Alzheimer's disease (heterozygote APP23 mice with the "Swedish double mutation"). To differentiate between unspecific effects of the transgenic model and specific Alzheimer effects, we additionally evaluated MAC values in mice with the same genetic construct but without the Alzheimer's disease-causing Swedish double mutation (heterozygote APP51/16 mice). Methods: MAC was determined in 60 mice (10 per group): heterozygote APP23 mice and their wild type littermates at the age of 4 and 18 mo, respectively, and heterozygote APP51/16 mice and their wild type littermates at the age of 18 mo. Anesthesia was induced with isoflurane in oxygen/air. The concentration of inhaled isoflurane varied between 1.0 and 2.0 Vol%, and the motor reaction to toeclamping was recorded. Means of the MAC values were compared with an unpaired t-test. Results: The MAC of 18-mo-old heterozygote APP23 mice was 1.67 ± 0.09, i.e., 9% larger than the MAC of their wild type littermates (1.53 ± 0.14; P = 0.020). Heterozygote APP51/16 mice had a lower MAC than their wild type littermates (1.32 ± 0.14 vs 1.48 ± 0.13; P = 0.037). All wild type groups and young heterozygote APP23 mice had comparable MAC values. Conclusions: The increased MAC value in aged heterozygote APP23 mice seems to be attributable to changes related to Alzheimer's disease.
AB - Background: More than 12% of all people older than 65 yr have Alzheimer's disease. Because nothing is known about changes in demand of volatile anesthetics in this disease, we determined minimum alveolar anesthetic concentration (MAC) values of isoflurane in young and aged transgenic mice at risk of developing Alzheimer's disease (heterozygote APP23 mice with the "Swedish double mutation"). To differentiate between unspecific effects of the transgenic model and specific Alzheimer effects, we additionally evaluated MAC values in mice with the same genetic construct but without the Alzheimer's disease-causing Swedish double mutation (heterozygote APP51/16 mice). Methods: MAC was determined in 60 mice (10 per group): heterozygote APP23 mice and their wild type littermates at the age of 4 and 18 mo, respectively, and heterozygote APP51/16 mice and their wild type littermates at the age of 18 mo. Anesthesia was induced with isoflurane in oxygen/air. The concentration of inhaled isoflurane varied between 1.0 and 2.0 Vol%, and the motor reaction to toeclamping was recorded. Means of the MAC values were compared with an unpaired t-test. Results: The MAC of 18-mo-old heterozygote APP23 mice was 1.67 ± 0.09, i.e., 9% larger than the MAC of their wild type littermates (1.53 ± 0.14; P = 0.020). Heterozygote APP51/16 mice had a lower MAC than their wild type littermates (1.32 ± 0.14 vs 1.48 ± 0.13; P = 0.037). All wild type groups and young heterozygote APP23 mice had comparable MAC values. Conclusions: The increased MAC value in aged heterozygote APP23 mice seems to be attributable to changes related to Alzheimer's disease.
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U2 - 10.1213/ANE.0b013e3181b76383
DO - 10.1213/ANE.0b013e3181b76383
M3 - Review article
C2 - 19820237
AN - SCOPUS:76249087223
SN - 0003-2999
VL - 110
SP - 438
EP - 441
JO - Anesthesia and analgesia
JF - Anesthesia and analgesia
IS - 2
ER -