Translational control: A target for cancer therapy

Saritha C. Thumma; Robert A Kratzke

doi:10.1016/j.canlet.2007.08.022

Translational control: A target for cancer therapy

Saritha C. Thumma, Robert A Kratzke

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

Cap-mediated translation is the default mechanism for the synthesis of proteins in eukaryotic cells. Increasingly, malignant cells have been found to have deregulation of this process. Return of normal translational control is associated with loss of tumorigenic potential in pre-clinical models. Currently, a variety of novel therapeutics are in development targeting this mechanism as a treatment for cancer.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Cancer Letters
Volume	258
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2007.08.022
State	Published - Dec 8 2007

Keywords

Cap-dependent
Translation
eIF4E
eIF4F

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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KW - Cap-dependent

KW - Translation

KW - eIF4E

KW - eIF4F

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Translational control: A target for cancer therapy

Abstract

Keywords

UN SDGs

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