Transposition of reversed Ac element ends generates novel chimeric genes in maize

Jianbo Zhang, Feng Zhang, Thomas Peterson

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The maize Activator/Dissociation (Ac/Ds) elements are members of the hAT (hobo, Ac, and Tam3) superfamily of type II (DNA) transposons that transpose through a "cut-and-paste" mechanism. Previously, we reported that a pair of Ac ends in reversed orientation is capable of undergoing alternative transposition reactions that can generate large-scale chromosomal rearrangements, including deletions and inversions. We show here that rearrangements induced by reversed Ac ends transposition can join the coding and regulatory sequences of two linked paralogous genes to generate a series of chimeric genes, some of which are functional. To our knowledge, this is the first report demonstrating that alternative transposition reactions can recombine gene segments, leading to the creation of new genes.

Original languageEnglish (US)
Pages (from-to)1535-1540
Number of pages6
JournalPLoS genetics
Volume2
Issue number10
DOIs
StatePublished - Oct 2006

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