TREATMENT OF CUTANEOUS T-CELL LYMPHOMA (MYCOSIS FUNGOIDES) WITH 13-CIS-RETINOIC ACID

John F. Kessler; Norman Levine; Frank L. Meyskens; Peter J. Lynch; Stephen E. Jones

doi:10.1016/S0140-6736(83)92136-0

TREATMENT OF CUTANEOUS T-CELL LYMPHOMA (MYCOSIS FUNGOIDES) WITH 13-CIS-RETINOIC ACID

John F. Kessler, Norman Levine, Frank L. Meyskens, Peter J. Lynch, Stephen E. Jones

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Abstract

Four patients with refractory cutaneous T-cell lymphoma (mycosis fungoides) were treated with 13-cis-retinoic acid. Near complete clearing of extensive tumours and plaques was seen in one patient, who remains in partial remission with continued improvement after fifteen months. Two patients showed improvement in pruritus and 50% reduction in plaques by four and six weeks, respectively. The fourth patient had improvement in pruritus and clearing of plaques, but dryness and scaling necessitated reduction and eventually withdrawal of the treatment.

Original language	English (US)
Pages (from-to)	1345-1347
Number of pages	3
Journal	The Lancet
Volume	321
Issue number	8338
DOIs	https://doi.org/10.1016/S0140-6736(83)92136-0
State	Published - Jun 18 1983
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by grants from the NIH (CA 27502, CA 23074, CA 17094) and Hoffman-LaRoche, Inc.

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title = "TREATMENT OF CUTANEOUS T-CELL LYMPHOMA (MYCOSIS FUNGOIDES) WITH 13-CIS-RETINOIC ACID",

abstract = "Four patients with refractory cutaneous T-cell lymphoma (mycosis fungoides) were treated with 13-cis-retinoic acid. Near complete clearing of extensive tumours and plaques was seen in one patient, who remains in partial remission with continued improvement after fifteen months. Two patients showed improvement in pruritus and 50% reduction in plaques by four and six weeks, respectively. The fourth patient had improvement in pruritus and clearing of plaques, but dryness and scaling necessitated reduction and eventually withdrawal of the treatment.",

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doi = "10.1016/S0140-6736(83)92136-0",

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AU - Meyskens, Frank L.

AU - Lynch, Peter J.

AU - Jones, Stephen E.

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Y1 - 1983/6/18

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AB - Four patients with refractory cutaneous T-cell lymphoma (mycosis fungoides) were treated with 13-cis-retinoic acid. Near complete clearing of extensive tumours and plaques was seen in one patient, who remains in partial remission with continued improvement after fifteen months. Two patients showed improvement in pruritus and 50% reduction in plaques by four and six weeks, respectively. The fourth patient had improvement in pruritus and clearing of plaques, but dryness and scaling necessitated reduction and eventually withdrawal of the treatment.

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TREATMENT OF CUTANEOUS T-CELL LYMPHOMA (MYCOSIS FUNGOIDES) WITH 13-CIS-RETINOIC ACID

Abstract

Bibliographical note

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