Abstract
The scientific breakthrough proving that antiretroviral therapy (ART) can halt heterosexual HIV transmission came in the form of a landmark clinical trial conducted among serodiscordant couples. Study findings immediately informed global recommendations for the use of treatment as prevention in serodiscordant couples. The extent to which these findings are generalizable to other key populations or to groups exposed to HIV through nonsexual transmission routes (i.e., anal intercourse or unsafe injection of drugs) has since driven a large body of research. This review explores the history of HIV research in serodiscordant couples, the implications for management of couples, subsequent research on treatment as prevention in other key populations, and challenges in community implementation of these strategies.
| Original language | English (US) |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Publisher | Springer New York LLC |
| Pages | 125-162 |
| Number of pages | 38 |
| DOIs | |
| State | Published - 2018 |
| Externally published | Yes |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 1075 |
| ISSN (Print) | 0065-2598 |
| ISSN (Electronic) | 2214-8019 |
Bibliographical note
Funding Information:Led by University of California, San Francisco; funded by the US President’s Emergency Plan for AIDS Relief (US CDC)
Funding Information:
Led by the Africa Centre for Health and Population Studies; funded by the French National Agency for Aids and Viral Hepatitis Research (ANRS) and Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ)
Funding Information:
Led by the Harvard AIDS Initiative; funded by the US President’s Emergency Plan for AIDS Relief (US CDC)
Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2018.
Keywords
- HIV transmission
- Serodiscordant couples
- Treatment as prevention
