Treatment of HIV for the prevention of transmission in discordant couples and at the population level

M. Kumi Smith, Britta L. Jewell, Timothy B. Hallett, Myron S. Cohen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The scientific breakthrough proving that antiretroviral therapy (ART) can halt heterosexual HIV transmission came in the form of a landmark clinical trial conducted among serodiscordant couples. Study findings immediately informed global recommendations for the use of treatment as prevention in serodiscordant couples. The extent to which these findings are generalizable to other key populations or to groups exposed to HIV through nonsexual transmission routes (i.e., anal intercourse or unsafe injection of drugs) has since driven a large body of research. This review explores the history of HIV research in serodiscordant couples, the implications for management of couples, subsequent research on treatment as prevention in other key populations, and challenges in community implementation of these strategies.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages125-162
Number of pages38
DOIs
StatePublished - 2018
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1075
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Funding Information:
Led by University of California, San Francisco; funded by the US President’s Emergency Plan for AIDS Relief (US CDC)

Funding Information:
Led by the Africa Centre for Health and Population Studies; funded by the French National Agency for Aids and Viral Hepatitis Research (ANRS) and Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ)

Funding Information:
Led by the Harvard AIDS Initiative; funded by the US President’s Emergency Plan for AIDS Relief (US CDC)

Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2018.

Keywords

  • HIV transmission
  • Serodiscordant couples
  • Treatment as prevention

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