Tunneling nanotubes: Intercellular conduits for direct cell-to-cell communication in cancer

Emil Lou; Subree Subramanian

doi:10.1007/978-94-017-7380-5_8

Tunneling nanotubes: Intercellular conduits for direct cell-to-cell communication in cancer

Emil Lou, Subree Subramanian

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Tunneling nanotubes (TNTs) are actin-based cytoplasmic extensions that directly transfer cellular cargo between connected cells. Intercellular transport of signaling molecules and regulatory RNAs are an integral part of defining the tumor microenvironment and intratumoral heterogeneity. The TNT-based cellular mode of molecular signaling affects multiple cell functions including cellular reprograming, tumor evasion, and chemotherapy resistance. In this chapter we will discuss various concepts of intercellular communication in cancer via TNTs and highlight the potential role played by TNTs in cancer pathobiology.

Original language	English (US)
Title of host publication	Intercellular Communication In Cancer
Publisher	Springer Netherlands
Pages	201-225
Number of pages	25
ISBN (Electronic)	9789401773805
ISBN (Print)	9789401773799
DOIs	https://doi.org/10.1007/978-94-017-7380-5_8
State	Published - Jan 1 2015

Keywords

Horizontal transfer
Intercellular communication
Intercellular nanotubes
Intercellular transfer
Long-range cellular communication
Molecular networking
Tumor heterogeneity
Tumor-stroma interactions
Tunneling nanotubes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1007/978-94-017-7380-5_8

OpenUrl availability

Full text

Cite this

@inbook{e0aa1660aff946de92162aabd7425919,

title = "Tunneling nanotubes: Intercellular conduits for direct cell-to-cell communication in cancer",

abstract = "Tunneling nanotubes (TNTs) are actin-based cytoplasmic extensions that directly transfer cellular cargo between connected cells. Intercellular transport of signaling molecules and regulatory RNAs are an integral part of defining the tumor microenvironment and intratumoral heterogeneity. The TNT-based cellular mode of molecular signaling affects multiple cell functions including cellular reprograming, tumor evasion, and chemotherapy resistance. In this chapter we will discuss various concepts of intercellular communication in cancer via TNTs and highlight the potential role played by TNTs in cancer pathobiology.",

keywords = "Horizontal transfer, Intercellular communication, Intercellular nanotubes, Intercellular transfer, Long-range cellular communication, Molecular networking, Tumor heterogeneity, Tumor-stroma interactions, Tunneling nanotubes",

author = "Emil Lou and Subree Subramanian",

year = "2015",

month = jan,

day = "1",

doi = "10.1007/978-94-017-7380-5_8",

language = "English (US)",

isbn = "9789401773799",

pages = "201--225",

booktitle = "Intercellular Communication In Cancer",

publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Tunneling nanotubes

T2 - Intercellular conduits for direct cell-to-cell communication in cancer

AU - Lou, Emil

AU - Subramanian, Subree

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Tunneling nanotubes (TNTs) are actin-based cytoplasmic extensions that directly transfer cellular cargo between connected cells. Intercellular transport of signaling molecules and regulatory RNAs are an integral part of defining the tumor microenvironment and intratumoral heterogeneity. The TNT-based cellular mode of molecular signaling affects multiple cell functions including cellular reprograming, tumor evasion, and chemotherapy resistance. In this chapter we will discuss various concepts of intercellular communication in cancer via TNTs and highlight the potential role played by TNTs in cancer pathobiology.

AB - Tunneling nanotubes (TNTs) are actin-based cytoplasmic extensions that directly transfer cellular cargo between connected cells. Intercellular transport of signaling molecules and regulatory RNAs are an integral part of defining the tumor microenvironment and intratumoral heterogeneity. The TNT-based cellular mode of molecular signaling affects multiple cell functions including cellular reprograming, tumor evasion, and chemotherapy resistance. In this chapter we will discuss various concepts of intercellular communication in cancer via TNTs and highlight the potential role played by TNTs in cancer pathobiology.

KW - Horizontal transfer

KW - Intercellular communication

KW - Intercellular nanotubes

KW - Intercellular transfer

KW - Long-range cellular communication

KW - Molecular networking

KW - Tumor heterogeneity

KW - Tumor-stroma interactions

KW - Tunneling nanotubes

UR - http://www.scopus.com/inward/record.url?scp=84957082516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957082516&partnerID=8YFLogxK

U2 - 10.1007/978-94-017-7380-5_8

DO - 10.1007/978-94-017-7380-5_8

M3 - Chapter

AN - SCOPUS:84957082516

SN - 9789401773799

SP - 201

EP - 225

BT - Intercellular Communication In Cancer

PB - Springer Netherlands

ER -

Tunneling nanotubes: Intercellular conduits for direct cell-to-cell communication in cancer

Abstract

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this