Ultra-short echo time spectroscopic imaging in rats: Implications for monitoring lipids in glioma gene therapy

Timo Liimatainen; Juhana Hakumäki; Ivan Tkáč; Olli Gröhn

doi:10.1002/nbm.1031

Ultra-short echo time spectroscopic imaging in rats: Implications for monitoring lipids in glioma gene therapy

Timo Liimatainen, Juhana Hakumäki, Ivan Tkáč, Olli Gröhn

Center for Magnetic Resonance Research

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We demonstrate the feasibility of using ultra-short echo time (TE = 2 ms) magnetic resonance spectroscopic imaging (MRSI) to detect intracranial mobile lipids in the rat brain. High-performance outer volume suppression and pre-localization were demonstrated in phantoms and by the total absence of signals arising from extra-cranial lipids in MRSI spectra from control rats. The sequence performance was tested on glioma-bearing BDIX rats. Fast-relaxing lipid signals were spatially varied within a glioma during herpes simplex virus thymidine kinase-mediated gene therapy, demonstrating the potential application of this method.

Original language	English (US)
Pages (from-to)	554-559
Number of pages	6
Journal	NMR in biomedicine
Volume	19
Issue number	5
DOIs	https://doi.org/10.1002/nbm.1031
State	Published - Aug 2006

Keywords

Lipids
STEAM
Short echo time
Spectroscopic imaging

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abstract = "We demonstrate the feasibility of using ultra-short echo time (TE = 2 ms) magnetic resonance spectroscopic imaging (MRSI) to detect intracranial mobile lipids in the rat brain. High-performance outer volume suppression and pre-localization were demonstrated in phantoms and by the total absence of signals arising from extra-cranial lipids in MRSI spectra from control rats. The sequence performance was tested on glioma-bearing BDIX rats. Fast-relaxing lipid signals were spatially varied within a glioma during herpes simplex virus thymidine kinase-mediated gene therapy, demonstrating the potential application of this method.",

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AU - Tkáč, Ivan

AU - Gröhn, Olli

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AB - We demonstrate the feasibility of using ultra-short echo time (TE = 2 ms) magnetic resonance spectroscopic imaging (MRSI) to detect intracranial mobile lipids in the rat brain. High-performance outer volume suppression and pre-localization were demonstrated in phantoms and by the total absence of signals arising from extra-cranial lipids in MRSI spectra from control rats. The sequence performance was tested on glioma-bearing BDIX rats. Fast-relaxing lipid signals were spatially varied within a glioma during herpes simplex virus thymidine kinase-mediated gene therapy, demonstrating the potential application of this method.

KW - Lipids

KW - STEAM

KW - Short echo time

KW - Spectroscopic imaging

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Ultra-short echo time spectroscopic imaging in rats: Implications for monitoring lipids in glioma gene therapy

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