Abstract
A series of urea compounds based on the tripeptide Phe-Trp-Lys were synthesized and pharmacologically characterized at the mouse melanocortin receptors. The results include identification of novel melanocortin receptor agonists with potencies ranging from nanomolar to micromolar.
Original language | English (US) |
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Pages (from-to) | 2079-2082 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 13 |
Issue number | 12 |
DOIs | |
State | Published - Jun 16 2003 |
Bibliographical note
Funding Information:This work has been supported by NIH Grant RO1-DK57080. Carrie Haskell-Luevano is a recipient of a Burroughs Wellcome Fund Career Award in the Biomedical Sciences. Special thanks to Jim Rocca, McKnight Brain Institute, University of Florida for help with NMR spectroscopy.