TY - JOUR
T1 - Urinary C-peptide as a measure of beta-cell function after a mixed meal in healthy subjects
T2 - Comparison of four-hour urine C-peptide with serum insulin and plasma C-peptide
AU - Hoogwerf, B. J.
AU - Barbosa, J. J.
AU - Bantle, J. P.
AU - Laine, D.
AU - Goetz, F. C.
PY - 1983
Y1 - 1983
N2 - Urinary C-peptide (UCP) is a noninvasive measure of integrated insulin production, and the usefulness of 24-h collections has been previously reported. Only small numbers of subjects have been studied using shorter urine collections. To see how well 4-h urine collections for C-peptide (UCP) correlate with serum immunoreactive insulin (SI) and plasma C-peptide (PCP), we studied 41 healthy subjects (19 men, 22 women) using as a stimulus a 600-kcal mixed meal and the same mixed meal after oral prednisone. UCP values correlated best with the area under the curves for SI (r = 0.457, P < 0.001) and PCP (r = 0.557, P < 0.001). UCP was also significantly correlated with peak SI (r = 0.382, P < 0.001), peak PCP (r = 0.496, P < 0.001), fasting SI (r = 0.297, P = 0.007), and fasting PCP (r = 0.341, P = 0.007) values. Urinary C-peptide was significantly correlated with SI and PCP concentrations in a broad range of physiologic values for SI and PCP supporting the usefulness of UCP as a simple, noninvasive measure of beta-cell function. Four-hour collections for UCP may be useful in further studies of beta-cell function.
AB - Urinary C-peptide (UCP) is a noninvasive measure of integrated insulin production, and the usefulness of 24-h collections has been previously reported. Only small numbers of subjects have been studied using shorter urine collections. To see how well 4-h urine collections for C-peptide (UCP) correlate with serum immunoreactive insulin (SI) and plasma C-peptide (PCP), we studied 41 healthy subjects (19 men, 22 women) using as a stimulus a 600-kcal mixed meal and the same mixed meal after oral prednisone. UCP values correlated best with the area under the curves for SI (r = 0.457, P < 0.001) and PCP (r = 0.557, P < 0.001). UCP was also significantly correlated with peak SI (r = 0.382, P < 0.001), peak PCP (r = 0.496, P < 0.001), fasting SI (r = 0.297, P = 0.007), and fasting PCP (r = 0.341, P = 0.007) values. Urinary C-peptide was significantly correlated with SI and PCP concentrations in a broad range of physiologic values for SI and PCP supporting the usefulness of UCP as a simple, noninvasive measure of beta-cell function. Four-hour collections for UCP may be useful in further studies of beta-cell function.
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U2 - 10.2337/diacare.6.5.488
DO - 10.2337/diacare.6.5.488
M3 - Article
C2 - 6400710
AN - SCOPUS:0020510003
SN - 0022-1120
VL - 6
SP - 488
EP - 492
JO - Unknown Journal
JF - Unknown Journal
IS - 5
ER -