Use of membrane proteins from Salmonella gallinarum for prevention of fowl typhoid infection in chickens.

K. Bouzoubaa, K. V. Nagaraja, J. A. Newman, B. S. Pomeroy

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Outer membrane protein isolated from Salmonella gallinarum was examined at different concentrations with or without a mineral-oil adjuvant for its immunogenicity and protection against live challenge. A formalin-killed whole-cell bacterin of the same organism was used for comparison. The results suggested that membrane proteins from S. gallinarum give better protection than formalin-killed whole-cell bacterin. Addition of an oil adjuvant to the protein appeared to increase the efficiency of the vaccine. When protein was given to chickens at 400 micrograms/100 g of live body weight, it produced 100% protection against oral challenge with S. gallinarum.

Original languageEnglish (US)
Pages (from-to)699-704
Number of pages6
JournalAvian Diseases
Volume31
Issue number4
DOIs
StatePublished - Jan 1 1987

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