Using IR vibrations to quantitatively describe and predict site-selectivity in multivariate Rh-catalyzed C-H functionalization

Elizabeth N. Bess, David M. Guptill, Huw M.L. Davies, Matthew S. Sigman

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Achieving selective C-H functionalization is a significant challenge that requires discrimination between many similar C-H bonds. Yet, reaction systems employing Rh2(DOSP)4 and Rh2(BPCP)4 were recently demonstrated to afford high levels of selectivity in the C-H insertion of carbenes into toluene-derived substrates. Herein, we explore the origin of this selectivity through a systematic analysis of substrate and reagent features that alter levels of selectivity from 20:1 to 1:610 for secondary (or tertiary)-to-primary benzylic C-H functionalization of toluene derivatives. Describing this variation using infrared vibrations and point charges, we have developed a mathematical model from which are identified features of the systems that determine levels of site-selectivity and are applied as predictive factors to describe the selectivity behavior of new substrate/reagent combinations.

Original languageEnglish (US)
Pages (from-to)3057-3062
Number of pages6
JournalChemical Science
Volume6
Issue number5
DOIs
StatePublished - May 1 2015

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2015.

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