Using isotemporal analyses to examine the relationships between daytime activities and cancer recurrence biomarkers in breast cancer survivors

Kelsie M. Full, Eileen Johnson, Michelle Takemoto, Sheri J. Hartman, Jacqueline Kerr, Loki Natarajan, Ruth E. Patterson, Dorothy D. Sears

Research output: Contribution to journalArticlepeer-review

Abstract

Background: For breast cancer survivors, moderate to vigorous physical activity (MVPA) is associated with improved survival. Less is known about the interrelationships of daytime activities (sedentary behavior [SB], light-intensity physical activity, and MVPA) and associations with survivors’ health outcomes. This study will use isotemporal substitution to explore reallocations of time spent in daytime activities and associations with cancer recurrence biomarkers. Methods: Breast cancer survivors (N = 333; mean age 63 y) wore accelerometers and provided fasting blood samples. Linear regression models estimated the associations between daytime activities and cancer recurrence biomarkers. Isotemporal substitution models estimated cross-sectional associations with biomarkers when time was reallocated from of one activity to another. Models were adjusted for wear time, demographics, lifestyle factors, and medical conditions. Results: MVPA was significantly associated with lower insulin, C-reactive protein, homeostatic model assessment of insulin resistance, and glucose, and higher sex hormone-binding globulin (all P < .05). Light-intensity physical activity and SB were associated with insulin and homeostatic model assessment of insulin resistance (both P < .05). Reallocating 18 minutes of SB to MVPA resulted in significant beneficial associations with insulin (−9.3%), homeostatic model assessment of insulin resistance (−10.8%), glucose (−1.7%), and sex hormone-binding globulin (7.7%). There were no significant associations when 79 minutes of SB were shifted to light-intensity physical activity. Conclusions: Results illuminate the possible benefits for breast cancer survivors of replacing time spent in SB with MVPA.

Original languageEnglish (US)
Pages (from-to)217-224
Number of pages8
JournalJournal of Physical Activity and Health
Volume17
Issue number2
DOIs
StatePublished - 2020

Bibliographical note

Funding Information:
This work was supported by funding from the National Cancer Institute (U54 CA155435-01). K.M.F. was supported by the National, Heart, Lung and Blood Institute of the National Institutes of Health under the award number T32 HL07779. S.J.H. was supported under the award number K07CA181323.

Publisher Copyright:
© 2020 Human Kinetics, Inc.

Keywords

  • Accelerometers
  • Insulin resistance
  • Lifestyle behaviors
  • Survivorship

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

Cite this