Vascular Structure and Function in Cancer Survivors after Hematopoietic Stem Cell Transplantation

Donald R. Dengel, Aaron S. Kelly, Lei Zhang, Qi Wang, James S. Hodges, Julia Steinberger, K. Scott Baker

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

This study examined the effects of hematopoietic cell transplantation (HCT) and associated preparative regimens on vascular structure and function. Measures of carotid artery stiffness and brachial artery endothelial-dependent dilation were obtained in patients who had survived ≥ 2 years after HCT for hematologic malignancy and were diagnosed at ≤21 years. HCT survivors (n = 108) were examined: 66 received total body irradiation (TBI) alone or with a low-dose cranial radiation boost (TBI±LD-CRT), 19 received TBI plus high-dose cranial radiation (TBI+HD-CRT), and 23 received a chemotherapy-only preparative regimen (CHEMO). Siblings (n = 83) were invited to participate as control subjects. Although endothelial-dependent dilation did not differ between siblings and HCT survivors, carotid cross-sectional compliance, cross-sectional distensibility, diameter compliance, and diameter distensibility were greater in siblings than HCT survivors. Comparing the HCT preparative regimens, carotid cross-sectional compliance, cross-sectional distensibility, diameter compliance, diameter distensibility, and incremental elastic modulus were significantly lower in the TBI+HD-CRT group compared with siblings or with TBI±LD-CRT and CHEMO treatment groups. Cross-sectional distensibility and diameter compliance were significantly lower in the TBI±LD-CRT group compared with siblings. TBI±LD-CRT and CHEMO groups did not differ from each other in these vascular measures. HCT preparative regimens containing TBI+HD-CRT resulted in greater arterial decrements, indicating increased risk for cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume25
Issue number1
DOIs
StatePublished - Jan 2019

Bibliographical note

Funding Information:
Financial disclosure: Supported by the National Institutes of Health (grants R01 CA113930 [to J.S.] and R01CA112530 [to K.S.B.]), the General Clinical Research Center Program (grant M01-RR00400), National Center for Research Resources (grant 1UL1-RR033183), and the Clinical and Translational Science Institute at the University of Minnesota-Twin Cities (grant UL1TR000114). Statistical support was provided by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funding Information:
Financial disclosure: Supported by the National Institutes of Health (grants R01 CA113930 [to J.S.] and R01CA112530 [to K.S.B.]), the General Clinical Research Center Program (grant M01-RR00400 ), National Center for Research Resources (grant 1UL1-RR033183 ), and the Clinical and Translational Science Institute at the University of Minnesota-Twin Cities (grant UL1TR000114 ). Statistical support was provided by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2018

Keywords

  • Cancer survivors
  • Compliance
  • Distensibility
  • Endothelial function
  • Ultrasound

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