Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure

Jocelyn M. Richard, Nakura Stout, Deanna Acs, Patricia H. Janak

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Despite its being historically conceptualized as a motor expression site, emerging evidence suggests the ventral pallidum (VP) plays a more active role in integrating information to generate motivation. Here, we investigated whether rat VP cue responses would encode and contribute similarly to the vigor of reward-seeking behaviors trained under Pavlovian versus instrumental contingencies, when these behavioral responses consist of superficially similar locomotor response patterns but may reflect distinct underlying decision-making processes. We find that cue-elicited activity in many VP neurons predicts the latency of instrumental reward seeking, but not of Pavlovian response latency. Further, disruption of VP signaling increases the latency of instrumental but not Pavlovian reward seeking. This suggests that VP encoding of and contributions to response vigor are specific to the ability of incentive cues to invigorate reward-seeking behaviors upon which reward delivery is contingent.

Original languageEnglish (US)
Article numbere33107
JournaleLife
Volume7
DOIs
StatePublished - Mar 22 2018
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health grants F32 AA022290 (JMR) and R01 AA014925 (PHJ), and by a NARSAD Young Investigator Award (JMR). The authors thank Alexandra Haimbaugh for technical assistance and Karen Wang for assistance with behavioral video tracking. National Institute on Alcohol Abuse and AlcoholismAA022290 Jocelyn M Richard Brain and Behavior Research Foundation Jocelyn M Richard National Institute on Alcohol Abuse and AlcoholismAA014925 Patricia Janak The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Funding Information:
This work was supported by National Institutes of Health grants F32 AA022290 (JMR) and R01 AA014925 (PHJ), and by a NARSAD Young Investigator Award (JMR). The authors thank Alexandra Haimbaugh for technical assistance and Karen Wang for assistance with behavioral video tracking.

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