Venturing into the New Science of Nucleases

Markéta Tolarová; John A. McGrath; Jakub Tolar

doi:10.1016/j.jid.2016.01.021

Venturing into the New Science of Nucleases

Markéta Tolarová, John A. McGrath, Jakub Tolar

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2 Scopus citations

Abstract

Gene editing with zinc finger nucleases, transcription activator-like effector nucleases, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated proteins system, or meganucleases can, in principle, mediate any genome modification. Recent studies have shown that COL7A1 mutations in cells of patients with recessive dystrophic epidermolysis bullosa can be corrected by homology-directed DNA repair.

Original language	English (US)
Pages (from-to)	742-745
Number of pages	4
Journal	Journal of Investigative Dermatology
Volume	136
Issue number	4
DOIs	https://doi.org/10.1016/j.jid.2016.01.021
State	Published - 2016

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Publisher Copyright:
© 2016 The Authors

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abstract = "Gene editing with zinc finger nucleases, transcription activator-like effector nucleases, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated proteins system, or meganucleases can, in principle, mediate any genome modification. Recent studies have shown that COL7A1 mutations in cells of patients with recessive dystrophic epidermolysis bullosa can be corrected by homology-directed DNA repair.",

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