Vertical transmission of hepatitis C virus

M. M. Thaler; D. W. Wara; G. Veereman-Wauters; D. V. Landers; R. L. Sweet; C. K. Park; M. Houghton; J. H. Han

doi:10.1016/0140-6736(91)90006-B

Vertical transmission of hepatitis C virus

M. M. Thaler, D. W. Wara, G. Veereman-Wauters, D. V. Landers, R. L. Sweet, C. K. Park, M. Houghton, J. H. Han

Obstetrics, Gynecology and Women's Health - Fetal Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

There is evidence that hepatitis C virus (HCV) may be vertically transmitted from infected mothers to their children. To test this hypothesis, we prospectively studied 10 pregnant women at high risk from parenterally or sexually transmitted diseases with the polymerase chain reaction. HCV RNA was found in 8 newborn babies delivered by women who were anti-HCV seropositive, and persisted for 2-19 months of follow-up. Anti-HCV detected in 7 infants cleared by 9 months and remained undetectable thereafter. Serum alanine aminotransferase was raised in 3 infants. The findings provide evidence of vertical transmission of HCV and suggest that perinatal infection may initiate a silent disease process or chronic carrier state.

Original language	English (US)
Pages (from-to)	17-18
Number of pages	2
Journal	The Lancet
Volume	338
Issue number	8758
DOIs	https://doi.org/10.1016/0140-6736(91)90006-B
State	Published - Jul 6 1991

Bibliographical note

Funding Information:
studies. This study was supported in part by the UC University-wide AIDS Research Program grant no R90SF225, the Bay Area Perinatal AIDS Center grant no NICHD 24640, and the Pediatrics Clinical Research Center grant no RR 01271.

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title = "Vertical transmission of hepatitis C virus",

abstract = "There is evidence that hepatitis C virus (HCV) may be vertically transmitted from infected mothers to their children. To test this hypothesis, we prospectively studied 10 pregnant women at high risk from parenterally or sexually transmitted diseases with the polymerase chain reaction. HCV RNA was found in 8 newborn babies delivered by women who were anti-HCV seropositive, and persisted for 2-19 months of follow-up. Anti-HCV detected in 7 infants cleared by 9 months and remained undetectable thereafter. Serum alanine aminotransferase was raised in 3 infants. The findings provide evidence of vertical transmission of HCV and suggest that perinatal infection may initiate a silent disease process or chronic carrier state.",

author = "Thaler, {M. M.} and Wara, {D. W.} and G. Veereman-Wauters and Landers, {D. V.} and Sweet, {R. L.} and Park, {C. K.} and M. Houghton and Han, {J. H.}",

note = "Funding Information: studies. This study was supported in part by the UC University-wide AIDS Research Program grant no R90SF225, the Bay Area Perinatal AIDS Center grant no NICHD 24640, and the Pediatrics Clinical Research Center grant no RR 01271.",

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AU - Wara, D. W.

AU - Veereman-Wauters, G.

AU - Landers, D. V.

AU - Sweet, R. L.

AU - Park, C. K.

AU - Houghton, M.

AU - Han, J. H.

N1 - Funding Information: studies. This study was supported in part by the UC University-wide AIDS Research Program grant no R90SF225, the Bay Area Perinatal AIDS Center grant no NICHD 24640, and the Pediatrics Clinical Research Center grant no RR 01271.

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Y1 - 1991/7/6

N2 - There is evidence that hepatitis C virus (HCV) may be vertically transmitted from infected mothers to their children. To test this hypothesis, we prospectively studied 10 pregnant women at high risk from parenterally or sexually transmitted diseases with the polymerase chain reaction. HCV RNA was found in 8 newborn babies delivered by women who were anti-HCV seropositive, and persisted for 2-19 months of follow-up. Anti-HCV detected in 7 infants cleared by 9 months and remained undetectable thereafter. Serum alanine aminotransferase was raised in 3 infants. The findings provide evidence of vertical transmission of HCV and suggest that perinatal infection may initiate a silent disease process or chronic carrier state.

AB - There is evidence that hepatitis C virus (HCV) may be vertically transmitted from infected mothers to their children. To test this hypothesis, we prospectively studied 10 pregnant women at high risk from parenterally or sexually transmitted diseases with the polymerase chain reaction. HCV RNA was found in 8 newborn babies delivered by women who were anti-HCV seropositive, and persisted for 2-19 months of follow-up. Anti-HCV detected in 7 infants cleared by 9 months and remained undetectable thereafter. Serum alanine aminotransferase was raised in 3 infants. The findings provide evidence of vertical transmission of HCV and suggest that perinatal infection may initiate a silent disease process or chronic carrier state.

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Vertical transmission of hepatitis C virus

Abstract

Bibliographical note

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