TY - JOUR
T1 - Whey peptides improve wound healing following caesarean section in rats
AU - Wang, Junbo
AU - Zhao, Ming
AU - Liang, Rui
AU - Zhang, Zhaofeng
AU - Zhao, Haifeng
AU - Zhang, Jiali
AU - Li, Tian
AU - Li, Yong
PY - 2010/12/14
Y1 - 2010/12/14
N2 - We sought to determine whether postcaesarean treatment with whey peptides (WP) affects the healing of skin and uterine incision in rats during puerperium. Forty-eight rats were randomly divided into two groups. After a caesarean section, twenty-four rats were intragastrically administered WP, while others were administered a control vehicle. On days 7, 14 and 21 after delivery, the serum total protein/albumin concentration, skin tensile strength, uterine bursting pressure, skin/uterine hydroxyproline (Hyp) concentration and histological characteristics of the scar were measured in eight rats in each group. In the WP group, the albumin concentration, skin tensile strength, uterine bursting pressure and Hyp concentration in the skin increased significantly on days 21, 7, 14 and 21, respectively. Low neutrophil count and smaller scar width in the skin incision were found in the WP group on day 7. Postcaesarean treatment with WP promoted significant wound healing in the skin incision, and had a significant wound healing potential in the uterus.
AB - We sought to determine whether postcaesarean treatment with whey peptides (WP) affects the healing of skin and uterine incision in rats during puerperium. Forty-eight rats were randomly divided into two groups. After a caesarean section, twenty-four rats were intragastrically administered WP, while others were administered a control vehicle. On days 7, 14 and 21 after delivery, the serum total protein/albumin concentration, skin tensile strength, uterine bursting pressure, skin/uterine hydroxyproline (Hyp) concentration and histological characteristics of the scar were measured in eight rats in each group. In the WP group, the albumin concentration, skin tensile strength, uterine bursting pressure and Hyp concentration in the skin increased significantly on days 21, 7, 14 and 21, respectively. Low neutrophil count and smaller scar width in the skin incision were found in the WP group on day 7. Postcaesarean treatment with WP promoted significant wound healing in the skin incision, and had a significant wound healing potential in the uterus.
KW - Abdominal skin
KW - Caesarean section
KW - Rat uterus
KW - Whey peptides
KW - Wound healing
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U2 - 10.1017/S0007114510002692
DO - 10.1017/S0007114510002692
M3 - Article
C2 - 20691127
AN - SCOPUS:78649982375
SN - 0007-1145
VL - 104
SP - 1621
EP - 1627
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 11
ER -