Several studies have suggested that Otu domain had de-ubiquitinating activity and Tudor domain was important for the formation of germ cells. Here, we reported a novel zebrafish ovary-specific gene containing Otu and Tudor domain, z-otu, which was expressed at stages I-III oocytes and embryonic stages from zygotes to early blastula during embryonic cells maintained their totipotency. Therefore, z-otu might link the ubiquitin signaling pathway to early oogenesis and maintaining the totipotency of embryonic cell.
|Original language||English (US)|
|Number of pages||7|
|Journal||Biochimica et Biophysica Acta - Gene Structure and Expression|
|State||Published - Dec 30 2005|
Bibliographical noteFunding Information:
This work was supported by grants from the ICGEB (International Center for Genetic Engineering and Biotechnology) (CRP/CHN02-01), the National Basic Research Program of China (No. 2004CB117400), and the National Natural Science Foundation of China (No. 30150005; No. 30270675).
Copyright 2008 Elsevier B.V., All rights reserved.
- Otu domain
- Tudor domain